Headspace vs thermal desorption: what is the difference?

Direct answer

Headspace samples vapour equilibrated above a sealed specimen; thermal desorption usually releases compounds previously collected on a sorbent or emitted from a material. Their sampling and calibration chains are different.

Selection checklist

• Define the sample matrix and target analytes.
• Confirm the applicable official or validated method.
• Match sample preparation, separation and detector response.
• Verify blanks, calibration, carryover and performance with the real sample.

Technical boundary

This page is selection guidance. It does not replace a standard method, instrument manual or laboratory validation.