GPC analysis vs GPC cleanup: what is the difference?

Direct answer

Analytical GPC/SEC characterises polymer molecular size distribution. GPC cleanup is sample preparation that separates matrix components before a different GC or HPLC determination.

Selection checklist

• Define the sample matrix and target analytes.
• Confirm the applicable official or validated method.
• Match sample preparation, separation and detector response.
• Verify blanks, calibration, carryover and performance with the real sample.

Technical boundary

This page is selection guidance. It does not replace a standard method, instrument manual or laboratory validation.