GC vs HPLC: which technique fits the sample?

Direct answer

GC generally fits volatile, thermally stable or derivatisable compounds; HPLC generally fits less volatile, thermally sensitive or strongly polar compounds. The official method and detector ultimately control the choice.

Selection checklist

• Define the sample matrix and target analytes.
• Confirm the applicable official or validated method.
• Match sample preparation, separation and detector response.
• Verify blanks, calibration, carryover and performance with the real sample.

Technical boundary

This page is selection guidance. It does not replace a standard method, instrument manual or laboratory validation.