Residual Solvent Analysis by Headspace GC

Application overview

Headspace GC can reduce non-volatile matrix loading in residual-solvent workflows, while vial equilibration, transfer conditions and calibration must be validated for the actual matrix.

Workflow questions

• What is the sample matrix and how is it collected or stored?
• Which analytes and concentration range must be covered?
• Which official or validated method controls preparation and detection?
• What blanks, calibration checks, recovery tests and carryover controls are required?

Configuration note

The sample-preparation device, chromatograph, detector, columns, gases and data system must be reviewed as one analytical chain.

No detection limit, recovery, repeatability or standards compliance is claimed without method-specific evidence.